Aptar CSP Launches Xcelerate Development Services to Fast-Track Active Packaging Solutions

Aptar CSP Technologies announces the launch of a complete solution service offering focusing on de-risking development and insuring speed-to-market. The new Xcelerate Development Services (Xcelerate) optimizes the active packaging development process through end-to-end expert insight, resulting in expedited speed-to-market.

Xcelerate combines Aptar CSP Technologies’ unique material science and active packaging solution and associated services with FreeThink Technologies’ leadership in accelerated predictive modeling in shelf-life determination. Utilizing FreeThink’s ASAPprime technology, an optimized active packaging solution product is modeled and tested without the need for expensive, time-consuming line trials. The result is a “right the first time” approach that virtually eliminates repetitive design processes and reformulations caused by stability test failures.

Aptar CSP Technologies offers a portfolio of services (research and development, clinical and stability studies, commercial planning and production, etc.) built around its proprietary 3 Phase Activ-Polymer technology platform, which is delivered in a variety of configurations:

  • Activ-Blister solutions control the internal atmosphere of individual blister cavities. Applied via CSP Technologies’ patented heat-staking process without the use of adhesives, the technology accommodates any tablet and capsule size;
  • For bottled medicines, Activ-Seal closures incorporate moisture and gas scavenging technology press-fit into an induction-sealed, tamper-evident screw cap;
  • The Activ-Vial portfolio consists of one-piece, flip-top desiccated vials and desiccated bottles across a range of sizes; and
  • Activ-Film was developed to enhance transdermal drug delivery systems (TDDS), which provide controlled delivery of active substances through the skin.

Xcelerate reduces the entire active packaging design, testing and implementation process. The comprehensive, hands-on approach also includes capabilities to produce clinical trial and stability samples, regulatory support, consulting and testing during commercial implementation.

Aptar CSP Technologies launched Xcelerate in response to the increased complexity of matching moisture- and oxygen-sensitive medicines to ideal packaging solutions. As drug companies produce more potent APIs, larger molecules and modified release profiles, there is increased risk for stability issues associated with moisture, oxygen and volatile reactives. Innovative dosage forms such as chewable and disintegrating tablets also face significant shelf life challenges with respect to humidity sensitivity. These products may also face the added challenge of global distribution demands in Climate Zones 3/4b (hot/humid).

Xcelerate’s customized process determines a drug product’s moisture and oxygen sensitivity using highly accelerated stability studies open to specified environmental conditions such as temperature, relative humidity and oxygen level, then uses modeling to create theoretical package designs. Once the optimal packaging sorbent levels are determined, laboratory, clinical and stability study sample supplies can be prepared for confirmation or actual use.

“Our complete solution of material science driven active packaging solutions, and the newly launched Xcelerate Development Services offer improved stability, extended shelf-life and expedited time-to-market for sensitive medicines,” said Craig Voellmicke, vice president, business development, Aptar CSP Technologies. “Together, they provide a valuable combination of effective drug protection and ease of adoption.”

For more information, visit www.aptar.com and www.freethinktech.com.

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